Ukrainian Journal of Veterinary Sciences

Clinical and morphological indicators of halitosis in cats

Mariia Kulida, Jakub Nicpoń , Pavlo Solonin, Vitaly Oliynyk
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Abstract

The relevance of this study is due to the increasing number of complaints from cat owners presenting to veterinary clinics regarding the occurrence of unpleasant odours from the oral cavity (halitosis) in their pets. Accordingly, the article focuses on identifying diseases and their clinical manifestations most commonly associated with the development of halitosis in cats. To assess the presence and progression of halitosis, case histories were collected, and clinical examinations of the oral cavity were performed. The most frequent oral pathologies accompanied by unpleasant odours were identified. It was found that in 27% of the examined animals, halitosis developed against the background of chronic gingivostomatitis. In 14% of cases, it was associated with stomatitis and dental calculus, while in 13% it resulted from tooth resorption. Viral diseases of the oral cavity were diagnosed in 11% of the animals. Gingivitis (8%), periodontitis (7%), and oral neoplasms (7%) were among the least frequently diagnosed conditions in cats with halitosis. Morphological and biochemical blood studies in animals with chronic gingivostomatitis accompanied by halitosis revealed specific changes in haematological parameters, corresponding to underlying pathological processes. According to the results of clinical analysis of native blood from cats with chronic gingivostomatitis and clinical signs of halitosis, the white blood cell count increased by 88.6% (P < 0.001), eosinophils by 1.7 times (P < 0.05), while the number of platelets and red blood cells decreased by 1.5 times (P < 0.001) and 1.2 times (P < 0.05), respectively, in comparison with clinically healthy animals. These patterns indicate pronounced destructive changes in the cells of the oral mucosa and associated tissues and organs. This material is of practical relevance for veterinary practitioners and is important for use in the diagnosis and prognosis of diseases presenting with halitosis, as well as in selecting an optimal treatment strategy and monitoring its effectiveness

Keywords

oral cavity; gingivitis; stomatitis; chronic gingivostomatitis; tongue ulcer; squamous cell carcinoma

Suggested citation
Kulida, M., Nicpoń , J., Solonin, P. , & Oliynyk, V. (2025). Clinical and morphological indicators of halitosis in cats. Ukrainian Journal of Veterinary Sciences, 16(1), 104-122. https://doi.org/10.31548/veterinary1.2025.104
References

[1] Anderson, J.G., & Hennet, P. (2022). Management of severe oral inflammatory conditions in dogs and cats. The Veterinary Clinics of North America. Small Animal Practice, 52(1), 159-184. doi: 10.1016/j.cvsm.2021.09.008.

[2] Anderson, J.G., et al. (2023). The oral microbiome across oral sites in cats with chronic gingivostomatitis, periodontal disease, and tooth resorption compared with healthy cats. Animals, 13(22), article number 3544. doi: 10.3390/ani13223544.

[3] Araujo, L.D.C., Furlaneto, F.A.C., da Silva, L.A.B., & Kapila, Y.L. (2022). Use of the probiotic Bifidobacterium animalis subsp. lactis HN019 in oral diseases. International Journal of Molecular Sciences, 23(16), article number 9334.  doi: 10.3390/ijms23169334.

[4] Bashor, L., et al. (2024). Impacts of antiretroviral therapy on the oral microbiome and periodontal health of feline immunodeficiency virus positive cats. Viruses, 17(2), article number 257. doi: 10.3390/v17020257.

[5] Bollen, C.M., & Beikler, T. (2012). Halitosis: The multidisciplinary approach. International Journal of Oral Science, 4(2), 55-63.  doi: 10.1038/ijos.2012.39.

[6] Caravalho, D.O L., et al. (2025). The association of infectious and parasitic pathogens in the etiology of chronic stomatitis and feline gingivostomatitis: A multifactorial approach. Revista Caderno Pedagógico, 22(1), article number e13636. doi: 10.54033/cadpedv22n1-242.

[7] Croft, J.M., Patel, K.V., Inui, T., Ruparell, A., Staunton, R., & Holcombe, L.J. (2022). Effectiveness of oral care interventions on malodour in dogs. BMC Veterinary Research, 18, article number 164.  doi: 10.1186/s12917-022-03267-8.

[8] Cunha, E., Tavares, L., & Oliveira, M. (2022). Revisiting periodontal disease in dogs: How to manage this new old problem? Antibiotics (Basel, Switzerland), 11(12), article number 1729. doi: 10.3390/antibiotics11121729.

[9] Dai, P., Yang, M., Du, J., Wang, K., Chen, R., Feng, X., Chen, C., & Zhang, X. (2024). Epidemiological investigation of feline chronic gingivostomatitis and its relationship with oral microbiota in Xi’an, China. Frontiers in Veterinary Science, 11, article number 1418101. doi: 10.3389/fvets.2024.1418101.

[10] Di Cerbo, A., Pezzuto, F., Canello, S., Guidetti, G., & Palmieri, B. (2015). Therapeutic effectiveness of a dietary supplement for management of halitosis in dogs. Journal of Visualized Experiments: JoVE, (101), article number e52717. doi: 10.3791/52717.

[11] Directive of the European Parliament and of the Council No. 2010/63/EU “On the Protection of Animals Used for Scientific Purposes”. (2010, September). Retrieved from https://eur-lex. europa.eu/eli/dir/2010/63/oj/eng/.

[12] European Convention for the Protection of Vertebrate Animals Used for Research and Other Scientific Purposes. (1986, March). Retrieved from https://zakon.rada.gov.ua/go/994_137.

[13] Fontes, A.C., Vieira, M.C., Oliveira, M., Lourenço, L., Viegas, C., Faísca, P., Seixas, F., Requicha, J.F., & Pires, M.A. (2023). Feline calicivirus and natural killer cells: A study of its relationship in chronic gingivostomatitis. Veterinary World, 16(8), 1708-1713. doi: 10.14202/ vetworld.2023.1708-1713.

[14] Guilherme-Fernandes, J., Fonseca, A.J.M., Aires, T., Lima, S.A.C., Maia, M.R.G., & Cabrita, A.R.J. (2024). Unveiling the effects of shrimp hydrolysate as a dietary ingredient in healthy adult Beagle dogs. Journal of Animal Science, 102, article number skae280.  doi: 10.1093/ jas/skae280.

[15] Hofmann-Lehmann, R., et al. (2022). Calicivirus infection in cats. Viruses, 14(5), article number 937. doi: 10.3390/v14050937.

[16] Kamlangchai, P., Kampa, N., Srithunyarat, T., Seesupa, S., Hoisang, S., Kaenkangploo, D., Jitasombuti, P., Nonthakotr, C., Boonbal, N., & Jitpean, S. (2024). Assessing the potential efficacy of 830-nanometer low-level laser therapy in cats: Extraoral applications. Veterinary World, 17(5), 1124-1129. doi: 10.14202/vetworld.2024.1124-1129.

[17] Khomyn, N., Mysak, A., Tsisinska, S., Pritsak, V., Nazaruk, N., & Khomyn, M. (2020). Comprehensive treatment of dogs with chronic generalized periodontitis in remission. Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies. Series: Veterinary Sciences, 22(98), 57-62. doi: 10.32718/nvlvet9810.

[18] Kim, D.H., Kwak, H.H., & Woo, H.M. (2023). Prevalence of feline chronic gingivostomatitis in feral cats and its risk factors. Journal of Feline Medicine and Surgery, 25(1), article number 1098612X221131453. doi: 10.1177/1098612X221131453.

[19] Law of Ukraine No. 3447-IV “On the Protection of Animals from Cruelty”. (2006, February). Retrieved from https://zakon.rada.gov.ua/go/3447-15.

[20] Oba, P.M., Sieja, K.M., Schauwecker, A., Somrak, A.J., Hristova, T.S., Keating, S.C.J., & Swanson, K.S. (2024). Effects of a novel dental chew on oral health outcomes, halitosis, and microbiota of adult dogs. Journal of Animal Science, 102, article number skae071.  doi: 10.1093/jas/skae071.

[21] Ohira, C., Kaneki, M., Shirao, D., Kurauchi, N., & Fukuyama, T. (2025). Oral treatment with catechin isolated from Japanese green tea significantly inhibits the growth of periodontal pathogen Porphyromonas gulae and ameliorates the gingivitis and halitosis caused by periodontal disease in cats and dogs. International Immunopharmacology, 146, article number 113805. doi: 10.1016/j.intimp.2024.113805.

[22] Oskarsson, K., Axelsson Puurtinen, L., & Penell, J.C. (2021). Dental problems and prophylactic care in cats-knowledge and perceptions among Swedish cat owners and communication by veterinary care staff. Animals, 11(9), article number 2571.  doi: 10.3390/ani11092571.

[23] Park, M.K., & Song, K.H. (2024). Case report: Allogeneic feline umbilical cord-derived mesenchymal stem cell transplantation for feline oral squamous cell carcinoma. Frontiers in Veterinary Science, 11, article number 1443110. doi: 10.3389/fvets.2024.1443110.

[24] Rodrigues, M.X., Bicalho, R.C., Fiani, N., Lima, S.F., & Peralta, S. (2019). The subgingival microbial community of feline periodontitis and gingivostomatitis: Characterization and comparison between diseased and healthy cats. Scientific Reports, 9(1), article number 12340. doi: 10.1038/s41598-019-48852-4.

[25] Soltero-Rivera, M., Shaw, C., Arzi, B., Lommer, M., & Weimer, B.C. (2024). Feline chronic gingivostomatitis diagnosis and treatment through transcriptomic insights. Pathogens (Basel, Switzerland), 13(3), article number 192.  doi: 10.3390/pathogens13030192.

[26] Taylor, S., Gruen, M., KuKanich, K., Lascelles, B.D., Monteiro, B.P., Sampietro, L.R., Robertson, S., & Steagall, P.V. (2024). 2024 ISFM and AAFP consensus guidelines on the long-term use of NSAIDs in cats. Journal of Feline Medicine and Surgery, 26(4), article number 1098612X241241951. doi: 10.1177/1098612X241241951.

[27] Villatoro, A.J., Martín-Astorga, M.D.C., Alcoholado, C., Kazantseva, L., Cárdenas, C., Fariñas, F., Becerra, J., & Visser, R. (2022). Secretory profile of adipose-tissue-derived mesenchymal stem cells from cats with calicivirus-positive severe chronic gingivostomatitis. Viruses, 14(6), article number 1146. doi: 10.3390/v14061146.

[28] Voloboieva, U.I., Bilyi, D.D., & Stotskyi, O. (2023). Prevalence and risk factors of dental disease in dogs (overview). Bulletin of Sumy National Agrarian University. The Series: Veterinary Medicine, 3(62), 21-28. doi: 10.32782/bsnau.vet.2023.3.3.

[29] Voloboieva, U.І., & Bilyi, D.D. (2024). Clinical rationale of diagnostic approaches in the dental examination of dogs. Theoretical and Applied Veterinary Medicine, 12(2), 24-30. doi: 10.32819/2024.12009.

[30] Wei, Y., Zeng, Q., Gou, H., & Bao, S. (2024). Update on feline calicivirus: Viral evolution, pathogenesis, epidemiology, prevention and control. Frontiers in Microbiology, 15, article number 1388420. doi: 10.3389/fmicb.2024.1388420.

[31] Zhang, M., Cui, Y., Mei, X., Li, L., Wang, H., Li, Y., & Wu, Y. (2024). Effect of dietary composite probiotic supplementation on the microbiota of different oral sites in cats. Veterinary Sciences, 11(8), article number 351.  doi: 10.3390/vetsci11080351.