Ukrainian Journal of Veterinary Sciences

In recent years, there is a tendency to increase the incidence of the disease in dogs with signs of diarrhea, not only in Ukraine but also in Europe. The article presents the results of a study on histological changes in organs and tissues of dogs with coronavirus infection. A histological study of pathological material sampled from 6 dogs of various breeds and gender, aged from 2 to 6 months, died from diarrheal syndrome was carried out. The presence of the coronavirus was confirmed in fecal samples by a polymerase chain reaction. The most expressed injuries and typical changes in all dead dogs we recorded in the small intestine, namely in the jejunum and ileum, regional lymph nodes, and also the spleen. Morphological manifestations of coronavirus infection in dogs at the macroscopic level are the following signs: the presence of exudative inflammation in the small intestine in form of serofibrinous jejunoileitis, hyperplasia and serohemorrhagic lymphadenitis of the mesenteric lymph nodes, multiple foci of hemorrhage in the parenchyma of the spleen and serous membrane of the small intestine, passive venous hyperemia of the liver and kidneys, dilatation of the right ventricle of the heart, pulmonary edema, cachexia and dehydration of the body. At the microscopic level, we registered the following: serofibrinous jejunoileitis, hyperplasia of the lymphoid nodules of the spleen and lymph nodes, hemorrhagic infarctions in the spleen, hyperplasia of individual and aggregated lymphoid nodules in the small intestinal mucosa, degenerative processes in the parenchyma of the liver and kidneys. 

coronavirus infection, dogs, histological changes, hemorrhages, serofibrinous jejunoileitis, serohemorrhagic lymphadenitis, hyperplasia, lymphoid nodules