The increasing incidence of pulmonary fibrosis in animals caused by toxic exposure necessitates a detailed analysis of radiological changes in lung tissue. This is essential for assessing the progression of fibrosis and developing effective therapeutic approaches. In this context, the study aimed to utilise radiological methods to identify time-dependent changes in the lungs of rats subjected to a model of bleomycin-induced pulmonary fibrosis, contributing to the improvement of diagnostic techniques for this pathological condition. Pulmonary fibrosis was experimentally induced in laboratory rats by administering bleomycin. Radiological examinations were conducted on days 7, 14, 30, and 45 to monitor the condition of lung tissue and detect progressive changes. Particular attention was given to identifying characteristic radiological signs of fibrosis, such as lung tissue consolidation and reduced transparency. The findings revealed a progressive nature of interstitial lesions. It was established that as early as seven days after bleomycin administration, signs of inflammation appeared in the lungs, accompanied by reduced transparency of the pulmonary fields. By day 14, initial signs of fibrosis were observed, marked by increased lung tissue density and the presence of infiltrates. By day 30 of pathology progression, significant fibrosis development was evident, characterised by more pronounced linear inclusions and reduced transparency. By day 45, scar tissue formation occurred, leading to substantial structural deterioration of the lungs. The findings highlighted the importance of radiological examination as an informative method for diagnosing and monitoring the progression of pulmonary fibrosis. The radiological changes observed at different stages of fibrosis development enable a more detailed characterisation of the disease pathogenesis, which is crucial for evaluating the effectiveness of therapeutic interventions. Accordingly, the study results could be utilised to establish new diagnostic criteria and enhance the monitoring of patients with pulmonary fibrosis
pulmonary fibrosis; radiographic imaging; interstitial lung disease; experimental model; laboratory rats; diagnosis
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