Ukrainian Journal of Veterinary Sciences

Presented results of histological investigation of liver and pancreas of 9 dogs died from the intestinal form of parvoviral infection. In the liver slides, painted by hematoxylin and eosin, hepatocytes initially show cellular swelling, which with the progressing of cellular damage turn into the hydropic degeneration, which characterize by the lysis of cytoplasmic structural components. After the lysis of lager part of cytoplasm cells destroyed. Hydropic degeneration from the fatty change differentiated by the painting by Sudan III. Degenerative changes of hepatocytes accompanied by destroying of the trabecular structure of liver lobules and decreasing of the lumen of sinusoid capillaries to the full obstruction of the part of such capillaries. In the pancreas microscopic changes of exocrine part of organ was irregular. The part of lobules has hypersecretion changes. In other lobules acinar cells has things of cellular swelling. At the areas of swelling cells, there was sites of its coagulative necrosis. In the pancreatic islands, there was the swelling and coagulative necrotic changes of all types of insular cells. All this microscopic changes permit to conclude, that the intestinal form of parvoviral infection lead to the development of the hepatopancreatic syndrome. 

dogs, parvoviral infection, intestinal form, liver, pancreas, microscopic changes, hepatopancreatic syndrome