Ukrainian Journal of Veterinary Sciences

Osteoarthritis is the most common disease of the joints, in which there is a disequilibrium between the processes of recovery and destruction in the cartilage and bone located under the cartilage, as well as in surrounding tissues: articular capsules, ligaments, muscles. For osteoarthritis, the structure of articular cartilage changes due to the loss of proteoglycans, which leads to its destruction, with atrophy of chondrocytes and the formation of new bone tissue around the affected joint. That is why studying morphological changes in the tissues of the knee joint allows us to confirm the presence of osteoarthritis. Studies have shown that chronic retinol acetate can be used to simulate chronic sclerosing osteoarthritis. Damage caused by retinol acetate can be identified as chronic sclerosing osteoarthritis. In this case, there is a thinning of the hyaline cartilage or its complete disappearance, the growth of dense fibrous connective tissue. Histologic studies have shown that there are horizontal unbranched cracks (fissures) in the cartilage tissue and in the fibrous connective tissue, the germs are thinned or absent. The main signs of such a defect are almost fully expressed at 7 days after the injury and classified as a 5-degree defeat (according to the classification of OARSI, 2000). 

knee joint, ostearthrosis modeling, rabbits, retinol acetate, chronic sclerosing osteoarthritis