Ukrainian Journal of Veterinary Sciences

The article presents the results of pathoanatomical changes in the laying hens organs at chronic experimental poisoning with neonicotinoids Aktara 25 WG and Mospylan RP. It was found that when feeding laying hens with feed containing Aktara 25 WG in different doses for 30 days caused increase in the mass index of spleen, decrease of this index of heart and liver. feeding laying hens with feed containing Mospylan RP in different doses for 30 days caused decrease of the mass indices of heart, liver, lung and glandular and muscular parts of stomach. Effect of Mospylan RP and Aktara 25 WG in doses of 65 mg/kg of body weight and 360 mg/kg of body weight respectively caused microscopic changes in hen’s kidneys such as serous glomerulonephritis, albuminous degeneration and destruction of part of the tubules’ epitheliocytes; in liver – edema, albuminous degeneration of hepatocytes; in the glandular part of the stomach – significant damage of mucosa; and necrosis of the small intestine mucosa. At preparations’ doses of 32.5 and 180 mg/kg of body weight respectively, it was registered total necrosis of hepatocytes in most loci of the liver. In those hens which were consumed feed contained Aktara 25 WG, it was registered edema of gray and white substances of the brain, basophilia in nerve cells and neuronophagy with the formation of glial nodules.

neonicotinoids, Mospilan, Aktara, laying hens, chronic toxicity, pathoanatomical changes